The "S3" program that formed the kernel of the Patriots is referenced as both the "Strangelove Simulation Software" and "Snatcher Substitution System."
Madnar's work in Outer Heaven building Metal Gear TX-55, eventually culminates in the Snatchers. Stangelove's contributions to the field of AI, combined with Dr. The Cameo: During Nebuchadnezzar's hallucination-based "The Reason You Suck" Speech, Paz has the last word.Nobunaga somehow got his hands on some high-frequency blades that can cleave bullets in two.Strangelove remembers meeting a fellow scientist in Tokyo in 1974 who talked about a new field, "nano-technology." When Frank Jaegar joins MSF, an exasperated Snake sends him off on an intel-gathering mission to Zanzibar, and randomly gives him the codename "Grey Fox" since he thinks "Null" is terrible and "Zero" and "Cipher" are both taken.She later declares, after taking out a spy in the second loop, that she'll still be awesome "even when I'm a granny". When Eva shows up and Snake comments that she's gained weight, she admits that she "had a few kids not too long ago" but couldn't keep them.Snake: Man, I don't even know what I'd do with one of me, let alone three. Except Shaka was exactly right about MSF being responsible for his war with Attila, even if Snake was unaware of Kaz's backroom dealing, and Shaka never engaged in open hostilities with MSF. Shaka is standoffish and unpleasant, and refuses to stop spying on MSF since he thinks they bribed the Huns to attack his empire, which leads to Snake declaring war and conquering the Zulu.And Now for Someone Completely Different: The interlude between the first and second campaigns shows off civilizations based on Puella Magi Madoka Magica.Already Done for You: Snake invades Wallachia so he can screen the place for Snatchers, but it turns out Vlad III already knew about that threat, and handled them the same way he solves all his problems.All Your Base Are Belong to Us: When Snake wakes up from his dream of diplomatic success, he finds that Nebuchadnezzar has somehow taken control of every one of MSF's cities except Mother Base.As is Chapter 50, when Snake thinks he's won a Diplomatic Victory.All Just a Dream: Chapter X: "Endless Snake" is the result of Nebuchadnezzar using his nightmare-inducing powers to mess with the heroes.Is a Crapshoot: Well, there's the Snatchers, but then it turns out the whole story was a simulation to prove to humanity that this trope isn't true.